Molecularly imprinted silica films prepared by electroassisted deposition for the selective detection of dopamine

SENSORS AND ACTUATORS B-CHEMICAL

卷:222

Article

Porcel-Valenzuela, Maria^1,2  Salinas-Castillo, Alfonso³  Morallon, Emilia^1,2  Montilla, Francisco^1,2 

[1] Univ Alicante, Dept Quim Fis, E-03080 Alicante, Spain

[2] Univ Alicante, Inst Univ Mat, E-03080 Alicante, Spain

[3] Univ Granada, Dept Analyt Chem, ECsens, E-18071 Granada, Spain

关键词: Molecular imprinting;    Electrodeposited silica;    Dopamine, Ascorbic acid;    Electrochemical sensor;   

DOI  :  10.1016/j.snb.2015.08.042

来源: Elsevier

【 摘 要 】

Dopamine (DA) can be detected by electrochemical oxidation in conventional electrodes. However, the presence of other oxidizable species (interferents) usually present in physiological fluids at high concentrations (like ascorbic acid) makes very difficult its electrochemical detection. In the present work, glassy carbon electrodes have been modified with molecularly imprinted silica (MIS) films prepared by electroassisted deposition of sol-gel precursors. The production of MIS films was performed by adding the template molecule (DA) to the precursor sol. The molecular impression of silica was assessed showing a high coherency allowing a filtering capacity in the molecular scale. The MIS-modified electrodes present a high selectivity for the detection of DA in neutral or acidic solutions. The MIS-modified electrodes allow the amperometric determination of dopamine in solutions containing ascorbic acid with molar ratios lower than 1:50,000. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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