Redox cycling-based electrochemical CMOS imaging sensor for real time and selective imaging of redox analytes

SENSORS AND ACTUATORS B-CHEMICAL

卷:304

Article

Abe, Hiroya^1,2,3  Yabu, Hiroshi²  Kunikata, Ryota⁴  Suda, Atsushi⁴  Matsudaira, Masahki⁵  Matsue, Tomokazu³ 

[1] Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan

[2] Tohoku Univ, WPI Adv Inst Mat Res, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan

[3] Tohoku Univ, Grad Sch Environm Studies, Aoba Ku, 6-6-11-604 Aramaki Aza, Sendai, Miyagi 9808579, Japan

[4] Japan Aviat Elect Ind Ltd, 1-1,Musashino 3 Chome, Akishima, Tokyo, Japan

[5] Tohoku Univ, Micro Syst Integrat Ctr, Aoba Ku, 519-1176 Aramaki Aza Aoba, Sendai, Miyagi, Japan

关键词: Electrochemical bioimaging;    Redox cycling;    Neurotransmitters;    Dopamine;    Cell analysis;   

DOI  :  10.1016/j.snb.2019.127245

来源: Elsevier

【 摘 要 】

In this study, we have developed a novel electrochemical device (IDEA-Bio-LSI) incorporating interdigitated electrodes array (IDEA) and a LSI-based amperometric device (Bio-LSI) for high speed (4-200 ms) and selective imaging of an analyte diffusion and cellar activities such as dopamine release. The amplification factor (eta(amp)) and capture efficiency (CE) of IDEA of the device were 2.17 and 0.767, respectively. Compared with previously reported IDE based imaging sensor, the acquisition speed of the present device to acquire one image was improved up to 50-250 times. In addition, the dopamine release from PC12 spheroids in the presence of ascorbic acid was successfully obtained by using the IDEA-Bio-LSI. Therefore, IDEA-Bio-LSI can apply to rapid analyte diffusion biological events such as release of dopamine release.

【 授权许可】

Free