Manganese ion chelated FeOCl@PB@PDA@BPQDs nanocomposites as a tumor microenvironment-mediated nanoplatform for enhanced tumor imaging and therapy

SENSORS AND ACTUATORS B-CHEMICAL

卷:307

Article

Zhang, Ming^1,2  Sheng, Bulei³  Ashley, Jon¹  Zheng, Tao¹  Wang, Wentao¹  Zhang, Qicheng²  Zhang, Jun²  Zhou, Ninglin²  Shen, Jian²  Sun, Yi¹ 

[1] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark

[2] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Peoples R China

[3] Aarhus Univ, Dept Food Sci, DK-8830 Tjele, Denmark

关键词: Tumor microenvironment;    Chemodynamic therapy;    Photodynamic therapy;    Photothermal therapy;    Multimodal imaging;   

DOI  :  10.1016/j.snb.2019.127491

来源: Elsevier

【 摘 要 】

Herein, a novel tumor microenvironment (TME)-mediated nanotheranostics platform of iron oxychloride (FeOCl) nanorods coated with Prussian Blue (PB), polydopamine (PDA), black phosphorus quantum dots (BPQDs) and chelated with Mn2+ was prepared. In the highly integrated nanoplatform (FeOCl@PB@PDA@ BPQDs@Mn), FeOCl catalysts exhibit supreme efficiency to yield hydroxyl radicals (center dot OH) by H2O2 decomposition for chemodynamic therapy (CDT). Moreover, the PB, FeOCl, and Mn2+ have a catalase-like activity that catalyze H2O2 to release of O-2 in the TME. Upon laser irradiation, the BPQDs transform O-2 to a singlet oxygen (O-1(2)) to self-enhance photodynamic therapy (PDT). Additionally, as a result of the high near-infrared (NIR) absorption rate and efficient photothermal conversion of PB and PDA, FeOCl@PB@PDA@BPQDs@Mn nanocomposites (NCs) are capable to work as ideal theranostic agents for photothermal therapy (PTT) in vitro and in vivo. Furthermore, FeOCl@PB@PDA@BPQDs@Mn NCs can also serve as multimodal imaging agents in different methods, such as magnetic resonance (MR), photoacoustic (PA), and ultrasound (US) imaging. Among the tumor models of mice, CDT, PDT, and PTT that combined with multimodal imaging achieved a more significant synergistic therapeutic result compared to any single treatment modality alone. Therefore, the multifunctional nanosystem in this study possesses tremendous potential in providing a satisfying paradigm for effective tumor treatment.

【 授权许可】

Free