Chemically polymerized polypyrrole for on-chip concentration of volatile breath metabolites

SENSORS AND ACTUATORS B-CHEMICAL

卷:143

Article

Strand, Nicholas¹  Bhushan, Abhinav¹  Schivo, Michael²  Kenyon, Nicholas J.²  Davis, Cristina E.¹ 

[1] Univ Calif Davis, Dept Mech & Aerosp Engn, Davis, CA 95616 USA

[2] Univ Calif Davis, Div Pulm & Crit Care Med, Genome & Biomed Sci Facil, Davis, CA 95616 USA

关键词: Polypyrrole;    Breath analysis;    Pre-concentration;    Adsorbent;    Biosensor;    MEMS;    Volatile organic compounds (VOCs);    Biomarker;   

DOI  :  10.1016/j.snb.2009.09.052

来源: Elsevier

【 摘 要 】

A wide range of metabolites are measured in the gas phase of exhaled human breath, and some of these biomarkers are frequently observed to be up- or down-regulated in certain disease states. Portable breath analysis systems have the potential for a wide range of applications in health diagnostics. However, this is currently limited by the lack of concentration mechanisms to enhance trace metabolites found in the breath to levels that can be adequately recorded using miniaturized gas-phase sensors. In this study we have created chip-based polymeric pre-concentration devices capable of absorbing and desorbing breath volatiles for subsequent chemical analysis. These devices appear to concentrate chemicals from both environmental air samples as well as directly from exhaled human breath, and these devices may have applications in lab-on-a-chip-based environmental and health monitoring systems. (C) 2009 Elsevier B.V. All rights reserved.

【 授权许可】

Free