Sample concentration in a microfluidic paper-based analytical device using ion concentration polarization

SENSORS AND ACTUATORS B-CHEMICAL

卷:222

Article

Dinh-Tuan Phan¹  Shaegh, Seyed Ali Mousavi²  Yang, Chun¹  Nam-Trung Nguyen³ 

[1] Nanyang Technol Univ, Sch Mech & Aerosp Engn, Singapore 639798, Singapore

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Griffith Univ, Queensland Micro & Nanotechnol Ctr, Brisbane, Qld 4111, Australia

关键词: Ion concentration polarization;    Paper-based microfluidics;    Sample concentration;    Nanofluidics;    Sample preparation;    Lab on a chip;   

DOI  :  10.1016/j.snb.2015.08.127

来源: Elsevier

【 摘 要 】

We report a low-cost approach for sample concentration in a microfluidic paper-based analytical device using ion concentration polarization. This device platform can attain liquid sample filling by capillary suction through the microporous paper and ion selective transport through a nanoporous polymer matrix under DC electric field. The device demonstrated a fast depletion of fluorescent dye samples and can serve as an effective microfluidic concentrator of fluorescent dye with 60-fold concentration enhancement achieved within 200 s. The device fabrication is simply based on paper cutting and lamination without the need of lithography and printing of hydrophobic material such as wax. The lamination approach presented in this paper has the potential to be transferred to a large-scale production of paper-based analytical devices. Published by Elsevier B.V.

【 授权许可】

Free