Wearable electrochemical glove-based sensor for rapid and on-site detection of fentanyl

SENSORS AND ACTUATORS B-CHEMICAL

卷:296

Article

Barfidokht, Abbas¹  Mishra, Rupesh K.¹  Seenivasan, Rajesh²  Liu, Shuyang¹  Hubble, Lee J.^1,3  Wang, Joseph¹  Hall, Drew A.^2,4 

[1] Univ Calif San Diego, Dept NanoEngn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA

[3] CSIRO Mfg, Lindfield, NSW 2070, Australia

[4] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

关键词: Fentanyl;    Glove based-sensor;    Opioids;    On-site drug screening;    Electrochemical;    Sensors;   

DOI  :  10.1016/j.snb.2019.04.053

来源: Elsevier

【 摘 要 】

Rapid, on-site detection of fentanyl is of critical importance, as it is an extremely potent synthetic opioid that is prone to abuse. Here we describe a wearable glove-based sensor that can detect fentanyl electrochemically on the fingertips towards decentralized testing for opioids. The glove-based sensor consists of flexible screen-printed carbon electrodes modified with a mixture of multiwalled carbon nanotubes and a room temperature ionic liquid, 4-(3-butyl-1-imidazolio)-1-butanesulfonate. The sensor shows direct oxidation of fentanyl in both liquid and powder forms with a detection limit of 10 mu M using square-wave voltammetry. The Lab-on-a-Glove sensors, combined with a portable electrochemical analyzer, provide wireless transmission of the measured data to a smartphone or tablet for further analysis. The integrated sampling and sensing methodology on the thumb and index fingers, respectively, enables rapid screening of fentanyl in the presence of a mixture of cutting agents and offers considerable promise for timely point-of-need screening for first responders. Such a glove-based swipe, scan, sense, and alert strategy brings chemical analytics directly to the user's fingertips and opens new possibilities for detecting substances of abuse in emergency situations.

【 授权许可】

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