Optimized CMOS photodetector structures for the detection of green luminescent probes in biological applications

SENSORS AND ACTUATORS B-CHEMICAL

卷:103

Article; Proceedings Paper

Yotter, RA ; Warren, MR ; Wilson, DM

关键词: photodetector;    photodiode;    stripe-shaped photodiode;    CMOS;    fluorescence detector;   

DOI  :  10.1016/j.snb.2004.04.035

来源: Elsevier

【 摘 要 】

Recent developments in lab-on-a-chip applications have increased the need for low-power, small-footprint photodetectors to detect luminescent reporters used to monitor biological events. Presented is a CMOS photodiode structure that is optimized to detect green light, the peak emission wavelength of commonly used fluorophores and other luminescent probes. The photodiode geometry uses a lightly doped striped cathode geometry to maximize the depletion region in areas of highest light absorbance, increasing the sensitivity to green light. The devices, realized in 1.5 mum CMOS technology, have up to a 63% increased signal-to-noise response for green light compared to blue-enhanced CMOS photodiode structures. These devices also generate an output 4.5 times larger than conventional CMOS detectors for detecting fluorescent emissions from a 1 muM fluorescein solution. The devices are designed to be integrated in total analysis systems which rely on the detection of fluorecent or phosphorescent reporters, and which are compact, low-power, and low-cost. (C) 2004 Elsevier B.V. All rights reserved.

【 授权许可】

Free