Clam-inspired nanoparticle immobilization method using adhesive tape as microchip substrate

SENSORS AND ACTUATORS B-CHEMICAL

卷:222

Article

Huang, Xiaowen^1,2  Zhu, Yujiao^1,2  Zhang, Xuming^1,2  Bao, Zhiyong²  Lei, Dang Yuan²  Yu, Weixing³  Dai, Jiyan²  Wang, Yu² 

[1] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Hong Kong, Peoples R China

[3] Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, State Key Lab Appl Opt, Changchun, Peoples R China

关键词: Microfluidics;    Biomimetics;    SERS;    Nanoparticle immobilization;    Biochip;    Microfabrication;   

DOI  :  10.1016/j.snb.2015.08.069

来源: Elsevier

【 摘 要 】

Immobilization of the suspended nanoparticles is essential for many microfluidic applications. This work reports a novel biomimetic method to immobilize nanoparticles by using a common adhesive tape as the substrate of microfluidic chip. It mimics the clams' feeding system that utilizes the mucus (i.e., sticky fluid) to capture small phytoplankton particles in water. This work proves experimentally that this method has a better immobilization effect and a stronger shear stress resistance than the traditional methods using hard glass substrates. Moreover, we have applied this method to immobilize Au nanorods for the detection of R6G of various concentrations using the surface-enhanced Raman scattering (SERS) effect. This method enjoys several major merits: the sticky adhesive tape can seal the microfluidic structure easily, avoiding the bonding process; the immobilization is easy and environmental friendly, without the need for expensive reagents or complex processes; the adhesive tape substrate allows the flexibility of microfluidic chips; and the adhesive tape substrate can be stripped off for off-chip detection and can be replaced easily for the reuse of microfluidic structures. With these, the biomimetic method may find potential applications in environmental sensing, biocatalysis and biosynthesis using microchips. (C) 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

【 授权许可】

Free