Effect of controlled sequential elevation timing of the head and thorax during cardiopulmonary resuscitation on cerebral perfusion pressures in a porcine model of cardiac arrest

RESUSCITATION

卷:149

Article

Rojas-Salvador, Carolina¹  Moore, Johanna C.^2,3  Salverda, Bayert³  Lick, Michael³  Debaty, Guillaume⁴  Lurie, Keith G.^2,3 

[1] Univ Minnesota, Dept Emergency Med, Minneapolis, MN USA

[2] Hennepin Healthcare, Dept Emergency Med, 701 Pk Ave, Minneapolis, MN 55417 USA

[3] Hennepin Healthcare Res Inst, Minneapolis, MN USA

[4] Univ Grenoble Alps, CHU Grenoble Alpes, CNRS, TIMC IMAG UMR 5525, Grenoble, France

关键词: Active compression-decompression CPR;    Cardiac arrest;    Cardiopulmonary resuscitation;    Cerebral perfusion pressure;    Coronary perfusion pressure;    Head Up CPR;    Head and thorax elevation;    Impedance threshold device;    Medical device;    Patient positioning;   

DOI  :  10.1016/j.resuscitation.2019.12.011

来源: Elsevier

【 摘 要 】

Aim: Controlled sequential elevation of the head and thorax (CSE) during active compression-decompression (ACD) CPR with an impedance threshold device (ITD) augments cerebral (CerPP) and coronary (CorPP) perfusion pressures. The optimal CSE is unknown. Methods: After 8 minutes of untreated VF, 40 kg anesthetized female pigs were positioned on a customized head and thorax elevation device (CED). After 2 min of automated ACD + ITD-16 CPR to 'prime the system', 12 pigs were randomized to CSE to the highest CED position over 4-min or 10-min. The primary outcome was CerPP after 7 minutes of CPR. Secondarily, 24-sec (without a priming step) and 2-min CSE times were similarly tested (n = 6 group) in a non-randomized order. Values expressed as mean +/- SD. Results: After 7 min of CPR, CerPPs were significantly higher in the 4-min vs 10-min CSE groups (53 +/- 14.4 vs 38.5 +/- 3.6 mmHg respectively, p = 0.03) whereas CorPP trended higher. The 4-min CSE group achieved 50% of baseline (50% BL) CerPP faster than the 10-min group (2.5 +/- 1.2 vs 6 +/- 3.1 minutes, p = 0.03). CerPP values in the 2-min and 4-min CSE groups were significantly higher than in the 24-sec group. With CSE, CerPPs and CorPPs increased over time in all groups. Conclusions: By optimizing controlled sequential elevation timing, CerPP values achieved 50% of baseline within less than 2.5 minutes and >80% of baseline after 7 minutes of CPR. This novel CPR approach rapidly restored CerPPs to near normal values non-invasively and without vasopressors.

【 授权许可】

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