Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations

PREVENTIVE MEDICINE

卷:140

Article

Higgins, Stephen T.¹  DeSarno, Michael¹  Davis, Danielle R.¹  Nighbor, Tyler¹  Streck, Joanna M.¹  Adise, Shana¹  Hartmann, Roxanne¹  Nesheim-Case, Riley¹  Markesich, Catherine¹  Reed, Derek²  Tyndale, Rachel F.^3,4  Gaalema, Diann E.¹  Heil, Sarah H.¹  Sigmon, Stacey C.¹  Tidey, Jennifer W.^1,5  Villanti, Andrea C.¹  Lee, Dustin⁶  Hughes, John R.¹  Bunn, Janice Y.¹ 

[1] Univ Vermont, Vermont Ctr Behav & Hlth, Burlington, VT 05401 USA

[2] Univ Kansas, Dept Appl Behav Sci, Lawrence, KS 66045 USA

[3] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Brown Univ, Ctr Alcohol & Addict Studies, Providence, RI 02912 USA

[6] Johns Hopkins Univ, Behav Pharmacol Res Unit, Sch Med, Baltimore, MD USA

关键词: Nicotine dependence;    Vulnerable populations;    Cigarette purchase task;    Relative reinforcing value;    Heaviness of smoking index;    Fagerstrom test for nicotine dependence;    Cotinine;   

DOI  :  10.1016/j.ypmed.2020.106189

来源: Elsevier

【 摘 要 】

We examined whether elucidating underpinning smoking motivation and related pharmacological processes enhances understanding of nicotine dependence among smokers from vulnerable populations. Data were obtained between Oct, 2016 and Sept, 2019 from 745 adult smokers with co-morbid psychiatric conditions or socioeconomic disadvantage at University of Vermont, Brown University, Johns Hopkins University. Smoking motivation was assessed using the Cigarette Purchase Task (CPT), a behavioral-economic task that models the relative reinforcing value of smoking under varying monetary constraint. Dependence severity was measured using the Heaviness of Smoking Index (HSI), Fagerstrom Test for Nicotine Dependence total scores (FTND), and FTND total scores minus items 1 and 4 (FTND2,3,5,6). We also assessed associations between dependence severity and smoking motivation with nicotine levels and metabolism rate. Principal Component Analysis was used to examine the latent structure of the conventional five CPT indices; bivariate and multivariable modeling was used to test associations. Factor analysis resulted in a two-factor solution, Amplitude (demand unconstrained by price) and Persistence (price sensitivity). CPT latent factors were associated with each dependence-severity measure (ps <= 0.0001), with associations stronger for Amplitude than Persistence across each, especially HSI which was exclusively associated with Amplitude. Amplitude and each dependence measure were associated with nicotine intake (ps <= 0.0002); Persistence was not (p =.19). Demand Amplitude more than Persistence appears key to understanding individual differences in dependence severity. Regarding potential application, the results suggest a need for interventions that more effectively target demand Amplitude to make greater headway in reducing smoking in vulnerable populations.

【 授权许可】

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