Impact of screening between the ages of 60 and 64 on cumulative rates of cervical cancer to age 84y by screening history at ages 50 to 59: A population-based case-control study

PREVENTIVE MEDICINE

卷:149

Article

Castanon, Alejandra¹  Green, Leonardo I.¹  Sasieni, Peter¹ 

[1] Guys Hosp, Sch Canc & Pharmaceut Sci, Fac Life Sci & Med, Canc Prevent Grp,Innovat Hub,Guys Canc Ctr, London SE1 9RT, England

关键词: Cervical cancer;    Cervical screening;    Older women;    Screening over age 65;    Cumulative risk;    Population rates;    Screening older women;   

DOI  :  10.1016/j.ypmed.2021.106625

来源: Elsevier

【 摘 要 】

There is little empirical data on the absolute benefit of cervical screening between ages 60-64y on subsequent cancer risk. We estimate the incidence of cervical cancer up to age 84y in women with and without a cervical cytology test at age 60-64y, by screening histories aged 50-59y. The current study is a population based casecontrol study of women born between 1928 and 1956 and aged 60-84y between 2007 and 2018. We included all such women diagnosed with cervical cancer in England and an aged-matched random sample without cancer. Women with a hysterectomy were excluded. Exposure was cervical cytology between ages 50-64y. The main outcome was 25y cumulative risk of cervical cancer between ages 60-84y. We found that eight in every 1000 (8.40, 95%CI: 7.78 to 9.07) women without a screening test between age 50-64y develop cervical cancer between the ages of 60-84y. The risk is half: 3.46 per 1000 (95%CI: 2.75 to 4.36) among women with a test between age 60-64y but no cervical screening test at age 50-59y. The absolute difference in risk is equivalent to one fewer cancer for every 202 such women screened. The highest risk (10.01, 95%CI:6.70 to 14.95) was among women with abnormal screening at ages 50-59y and no tests 60-64y. 25y risk among women with a screening test every five years between age 50-64y was just under two in a 1000 (1.59, 95%CI:1.42 to 1.78). Results suggest the upper age of screening should be dependent on previous screening participation and results.

【 授权许可】

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