Association of socioeconomic status with inflammatory markers: A two cohort comparison

PREVENTIVE MEDICINE

卷:71

Article

Fraga, Silvia¹  Marques-Vidal, Pedro²  Vollenweider, Peter^3,4  Waeber, Gerard^3,4  Guessous, Idris^2,5,6  Paccaud, Fred²  Barros, Henrique¹  Stringhini, Silvia² 

[1] Univ Porto, Inst Publ Hlth, EPIUnit, P-4100 Oporto, Portugal

[2] Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland

[3] CHU Vaudois, Dept Med, Lausanne, Switzerland

[4] Fac Biol & Med, Lausanne, Switzerland

[5] Univ Hosp Geneva, Unit Populat Epidemiol, Geneva, Switzerland

[6] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

关键词: Socioeconomic status;    Inflammation;    Switzerland;    Portugal;   

DOI  :  10.1016/j.ypmed.2014.11.031

来源: Elsevier

【 摘 要 】

Objective. To assess the association between socioeconomic status (SES) and inflammatory markers using two different European population samples. Methods. We used data from the CoLaus (N = 6412, Lausanne, Switzerland) and EPIPorto (N = 1205, Porto, Portugal) studies. Education and occupational position were used as indicators of socioeconomic status (SES). High-sensitivity C-reactive protein.(hs-CRP) was available for both cohorts. Interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were available in CoLaus; leukocyte count and fibrinogen in EPIPorto. Results. We showed that low SES was significantly associated with high inflammation in both studies. We also showed that behavioural factors contributed the most to SES differences in inflammation. In both studies the larger difference between the lowest and the highest SES was observed for hs-CRP. In the Swiss sample, a linear association between education and hs-CRP persisted after adjustment for all mediating factors and confounders considered (p for linear trend < 0.001). Conclusion. Large social differences exist in inflammatory activity, in part independently from demographic and behavioural factors, chronic conditions and medication use. SES differences in inflammation are also similar in countries with different underlying socioeconomic conditions. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free