Preterm birth rate after bivalent HPV vaccination: Registry-based follow-up of a randomized clinical trial

PREVENTIVE MEDICINE

卷:146

Article

Kalliala, Ilkka^1,2,3  Eriksson, Tiina⁴  Aro, Karoliina^1,2  Hokkanen, Mari⁴  Lehtinen, Matti^5,6  Gissler, Mika^7,8  Nieminen, Pekka^1,2 

[1] Univ Helsinki, Dept Obstet & Gynecol, Haartmaninkatu 2, Helsinki 00290, Finland

[2] Helsinki Univ Hosp, Haartmaninkatu 2, Helsinki 00290, Finland

[3] Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, Hammersmith Campus,Du Cane Rd, London W12 0NN, England

[4] Tampere Univ, Fican Mid, POB 100, FI-33014 Tampere, Finland

[5] Deutsch Krebsforschungszentrum, Infect & Canc Epidemiol, Neuenheimer Feld 242, D-69120 Heidelberg, Germany

[6] Karolinska Inst, Dept Lab Med, Alfred Nobels Alle 8,8th Floor, S-14152 Huddinge, Sweden

[7] THL Finnish Inst Hlth & Welf, Informat Serv Dept, Mannerheimintie 166, Helsinki 00300, Finland

[8] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Care Sci & Soc, Zanderska Huset,Alfred Nobels Alle 23, S-14183 Huddinge, Sweden

关键词: Preterm birth;    Human papillomavirus;    HPV;    Vaccine;   

DOI  :  10.1016/j.ypmed.2021.106473

来源: Elsevier

【 摘 要 】

A registry-based follow-up of pregnancy data until the end of 2014 was conducted based on a community randomized trial to assess human papillomavirus (HPV) vaccination strategies and a reference cohort from the same community with no intervention. Our objective was to determine whether prophylactic HPV vaccination (three doses of Cervarix? (AS04-HPV-16/18)-vaccine) affects preterm birth (PTB) rates. All identified 80,272 residents in 1992?95 birth cohorts in Finland were eligible for the trial and 20,513 of 39,420 (51.9%) females consented to participate. The final study population consisted of age-aligned 6226 HPV16/18 vaccinated females and 1770 HBV vaccinated (Engerix? B, hepatitis B-virus vaccine) females that did not receive HPV vaccine at the age of 18 from the 1992?93 birth cohorts, and 19,849 females from the 1990?91 non-vaccinated reference birth cohorts. We compared the rates of preterm (22 + 0?36 + 6 pregnancy weeks) and early preterm (22 + 0?31 + 6) per term (at least 37 + 0) singleton births among the HPVand non-HPV-vaccinated women, using nationwide Medical Birth Registry data. We observed 409 singleton first pregnancies lasting at least 22 + 0 weeks among 6226 HPV-vaccinated and 1923 among 21,619 non-HPV-vaccinated women. In the first pregnancy the PTB rate was 13/409 (3.2%) among the HPV-vaccinated and 98/1923 (5.1%) among the non-HPV-vaccinated (OR 0.61, 95% CI 0.34?1.09). Early preterm birth rate was 0/409 (0%) in the HPV-vaccinated women and 20/1923 (1.0%) in the non-HPV-vaccinated women (p = 0.04). PTB rate, especially early PTB rate, was lower among the HPVvaccinated women. Reduction of PTB incidence after prophylactic HPV vaccination would lead to public health benefits globally. Trial Registration:NCT00534638

【 授权许可】

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