Walking and inflammatory markers in individuals screened for type 2 diabetes

PREVENTIVE MEDICINE

卷:47

Article

Yates, Thomas¹  Davies, Melanie²  Brady, Emer²  Webb, David²  Gorely, Trish¹  Bull, Fiona¹  Talbot, Duncan³  Sattar, Naveed⁴  Khunti, Kamlesh⁵ 

[1] Univ Loughborough, Sch Sport & Exercise Sci, Loughborough LE11 3TU, Leics, England

[2] Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England

[3] Unilever Corp Res, Colworth Pk, Beds, England

[4] Univ Glasgow, Dept Vasc Biochem, Glasgow G12 8QQ, Lanark, Scotland

[5] Univ Leicester, Dept Hlth Sci, Leicester LE1 7RH, Leics, England

关键词: Adipocytokine;    C-reactive protein;    Exercise;    Inflammation;    Insulin;    Interleukin-6;    Physical activity;    Tumor necrosis factor-alpha;    Walking;   

DOI  :  10.1016/j.ypmed.2008.06.015

来源: Elsevier

【 摘 要 】

Objective. To investigate the association of walking activity with inflammatory markers and fasting insulin in a bi-ethnic population screened for type 2 diabetes in Leicester, United Kingdom, between 2005 and 2006. Method. Physical activity, adipocytokine, high-sensitivity C-reactive protein and fasting insulin measurements were available for 400 individuals screened for type 2 diabetes. Of the 400 participants, 56% were diagnosed with normal glucose control, 36% with prediabetes and 8% with diabetes. Results. Multivariate statistical analysis showed that those who reported walking for at least 30min on at least 5days/week had lower levels of C-reactive protein, interleukin-6, and tumor necrosis factor-et compared to those who reported lower walking activity levels, after adjustment for other modes of moderate-to-vigorous intensity physical activity, age, ethnicity, sex, social deprivation and smoking status. Further adjustment for waist circumference attenuated the association of walking with tumor necrosis factor-alpha. Conclusion. Walking activity, independent of other forms of physical activity, is associated with lower levels of circulating pro-inflammatory markers. (C) 2008 Elsevier Inc. All rights reserved

【 授权许可】

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