Repletion of vitamin D associated with deterioration of sleep quality among postmenopausal women

PREVENTIVE MEDICINE

卷:93

Article

Mason, Caitlin¹  Tapsoba, Jean de Dieu¹  Duggan, Catherine¹  Wang, Ching-Yun^1,2  Korde, Larissa^1,3  McTiernan, Anne^1,4 

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[2] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[3] Univ Washington, Dept Med, Seattle, WA USA

[4] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

关键词: 25-Hydroxyvitamin D;    Caloric restriction;    Exercise;    Quality of life;    Sleep;    Depression;   

DOI  :  10.1016/j.ypmed.2016.09.035

来源: Elsevier

【 摘 要 】

Reduced health-related quality of life (HRQOL), depressive symptoms and poor sleep quality are important health issues among postmenopausal women and may be associated with low vitamin D status. Overweight postmenopausal women, with serum 25-hydroxyvitamin D [25(OH) D] 10-32 ng/m, were recruited in Seattle, WA(2010-2012) and randomly assigned to 12 months of weight loss + 2000 IU oral vitamin D-3/day or weight loss + daily placebo. The weight-loss program included a reduced-calorie diet and 225 min/week of moderate-to-vigorous aerobic activity. Eight subscales of HRQOL were assessed by the MOS 36-ItemShort-Form Health Survey. Depressive symptoms were assessed using the Brief Symptom Inventory-18, and sleep quality was assessed using the Pittsburg Sleep Quality Index (PSQI). Mean 12-month changes in HRQOL, depressive symptoms and sleep quality were compared between groups (intent-to-treat) using generalized estimating equations. Compared to placebo, women receiving vitamin D did not experience any significant change in depressive symptoms (p = 0.78), HRQOL subscales (all p > 0.05), or overall sleep quality (p = 0.21). However, a greater magnitude of change in serum 25(OH) D was associated with an increased need to take medications to sleep (p(trend) = 0.01) and overall worse sleep quality (ptrend < 0.01). Women who became vitamin D replete (>= 32 ng/mL) also showed a deterioration in total PSQI sleep quality score compared to women who remained <32 ng/mL despite supplementation, even after adjusting for relevant covariates (Non-Replete: -5.7% vs. Replete: + 6.2%, p < 0.01). Vitamin D supplementation of 2000 IU/d may result in overall worse sleep quality for postmenopausal women with low circulating vitamin D undergoing weight loss. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

Free