Physical activity and cutaneous melanoma risk: A Norwegian population-based cohort study

PREVENTIVE MEDICINE

卷:153

Article

Perrier, Flavie¹  Ghiasvand, Reza^2,3  Lergenmuller, Simon¹  Robsahm, Trude E.³  Green, Adele C.^4,5,6  Borch, Kristin B.⁷  Sandanger, Torkjel M.⁷  Weiderpass, Elisabete⁸  Rueegg, Corina S.²  Veierod, Marit B.¹ 

[1] Univ Oslo, Oslo Ctr Biostat & Epidemiol, Inst Basic Med Sci, Dept Biostat, POB 1122, N-0317 Oslo, Norway

[2] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, Oslo, Norway

[3] Inst Populat Based Canc Res, Canc Registry Norway, Oslo, Norway

[4] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia

[5] Univ Manchester, Canc Res UK Manchester, Manchester, Lancs, England

[6] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England

[7] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[8] Int Agcy Res Canc, Lyon, France

关键词: Physical activity;    Ultraviolet radiation;    Cutaneous melanoma;    Cohort;    Women;    Norway;   

DOI  :  10.1016/j.ypmed.2021.106556

来源: Elsevier

【 摘 要 】

Physical activity (PA) is an important factor in cancer prevention, but positive association between PA and risk of cutaneous melanoma found in recent studies may complicate this strategy. Ultraviolet radiation (UVR) exposure during outdoor PA is a plausible explanation for a positive association. We investigated the associations between PA, UVR and melanoma risk in the Norwegian Women and Cancer cohort. Overall PA was reported by 151,710 women, aged 30-75 at inclusion, using a validated 10-point-scale at enrolment and during follow-up, together with recent numbers of sunburns, indoor tanning sessions and weeks on sunbathing vacations. Seasonal outdoor walking and seasonal PAs were recorded in subsamples (n = 102,671 and n = 29,077, respectively). Logistic and Cox regression were used. Mean follow-up was 18.5 years, and 1565 invasive incident melanoma cases were diagnosed. Overall PA was inversely associated with sunburns, while positively associated with sunbathing vacations and indoor tanning. Overall PA was not associated with melanoma risk in all body sites combined (ptrend = 0.61), but reduced risk was found in upper limb melanomas (hazard ratio (HR) = 0.70, 95% confidence interval (CI) 0.51-0.96; high versus low PA). Non-significant reduced risks were found for seasonal outdoor walking >2 h/day versus 30-60 min/day (summer HR = 0.81, 95% CI 0.66-1.00; autumn HR = 0.74, 95%CI 0.55-1.01). Seasonal PAs were not associated with melanoma risk. In conclusion, we found positive associations between overall PA and sunbathing vacations and indoor tanning, and, unlike literature, inverse association between overall PA and sunburns. Our results do not support a positive association between PA and melanoma risk in Norwegian women.

【 授权许可】

Free