Making preventive medicine more personalized: Implications for exercise-related research

PREVENTIVE MEDICINE

卷:55

Article

Buford, Thomas W.^1,2  Pahor, Marco¹ 

[1] Univ Florida, Dept Aging & Geriatr Res, Coll Med, Gainesville, FL 32611 USA

[2] Univ Florida, Coll Hlth & Human Performance, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA

关键词: Personalized medicine;    Physical activity;    Non-responder;    Genomics;    Phenomics;   

DOI  :  10.1016/j.ypmed.2012.05.001

来源: Elsevier

【 摘 要 】

Objective. This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine. Methods. We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training. Results. We argue that increased understanding is needed regarding sources of variability in exercise responsiveness, and that such understanding should lead to more tailored, often multimodal interventions. Conclusion. Studies of personalized medicine to date have primarily investigated heterogeneity in drug responsiveness; we believe it is time to begin considering preventive strategies such as exercise within a broader scope of personalized care. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

Free