Depression, antidepressants and low hemoglobin level in the Paris Prospective Study III: A cross-sectional analysis

PREVENTIVE MEDICINE

卷:135

Article

Vulser, Helene^1,2  Lemogne, Cedric^1,2,3  Boutouyrie, Pierre^1,4  Cote, Francine^1,5  Perier, Marie-Cecile^1,6  Van Sloten, Thomas^1,6,7,8  Hoertel, Nicolas^1,2,3  Danchin, Nicolas^1,9,10  Limosin, Frederic^1,2,3  Jouven, Xavier^1,6,9  Empana, Jean-Philippe^1,6 

[1] Univ Paris, Paris Descartes Fac Med, Paris, France

[2] Univ Paris, European Georges Pompidou Hosp, AP HP Ctr, Dept Psychiat, Paris, France

[3] Univ Paris, Inst Psychiat & Neurosci Paris IPNP, INSERM, UMR S1266, Paris, France

[4] Univ Paris, European Georges Pompidou Hosp, AP HP Ctr, Dept Pharmacol, Paris, France

[5] Univ Paris, Necker Enfants Malad Hosp, AP HP Ctr,Lab Excellence GR Ex, Dept Hematol,Inst Imagine,INSERM,U1183,CNRS,ERL 8, Paris, France

[6] INSERM, Paris Cardiovasc Res Ctr, Team Integrat Epidemiol Cardiovasc Dis 4, UMR S970, Paris, France

[7] Maastricht Univ, Cardiovasc Res Inst Maastricht, Med Ctr, Maastricht, Netherlands

[8] Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands

[9] Univ Paris, European Georges Pompidou Hosp, AP HP Ctr, Dept Cardiol, Paris, France

[10] Prevent & Clin Invest Ctr, Paris, France

关键词: Depression;    Hemoglobin;    Antidepressant;    Cohort study;    Epidemiology;   

DOI  :  10.1016/j.ypmed.2020.106050

来源: Elsevier

【 摘 要 】

Anemia is known to be associated with depression both in community and clinical populations. However, it is still unknown if this association depends or not on antidepressant intake. We investigated the respective association of depression and antidepressant intake with low hemoglobin level in a large community-based cohort. In 8640 volunteers aged 50 to 75 recruited between June 2008 and June 2012 in Paris (France), we assessed hemoglobin levels (g/dl), depressive symptoms and antidepressant intake. We examined the association of both depression and antidepressant intake with hemoglobin level, adjusting for numerous socio-demographic and health variables. We also assessed the association with specific antidepressant classes. Depression and anti-depressant intake were independently associated with lower hemoglobin level (beta = -0.074; p = .05 and beta = -0.100; p = .02 respectively in the fully-adjusted model). Regarding antidepressant classes, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) intake were associated with lower hemoglobin level (beta = -0.11; p = .01). To conclude, both depression and antidepressant intake were associated with lower hemoglobin level. In particular, as SSRI or SNRIs intake was also related to lower hemoglobin level, these classes should be used with caution in depressed individuals at risk for anemia.

【 授权许可】

Free