Breastfeeding and later maternal risk of hypertension and cardiovascular disease - The role of overall and abdominal obesity

PREVENTIVE MEDICINE

卷:114

Article

Kirkegaard, H.¹  Bliddal, M.^2,3  Stovring, H.⁴  Rasmussen, K. M.⁵  Gunderson, E. P.⁶  Kober, L.⁷  Sorensen, T. I. A.⁸  Nohr, E. A.^1,9 

[1] Univ Southern Denmark, Res Unit Obstet & Gynecol, Dept Clin Res, Klovervaenget 10,Entrance 112,10th Floor, DK-5000 Odense C, Denmark

[2] Univ Southern Denmark, Dept Clin Res, Odense Patient Data Explorat Network OPEN, JB Winslows Vej 9a 3rd Floor, DK-5000 Odense C, Denmark

[3] Odense Univ Hosp, JB Winslows Vej 9a 3rd Floor, DK-5000 Odense C, Denmark

[4] Aarhus Univ, Dept Publ Hlth, Biostat, Bartholins Alle 2, DK-8000 Aarhus C, Denmark

[5] Cornell Univ, Div Nutr Sci, 111 Savage Hall, Ithaca, NY 14853 USA

[6] Kaiser Permanente Northern Calif, Cardiovasc & Metab Condit Sect, Div Res, 2000 Broadway, Oakland, CA 94612 USA

[7] Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

[8] Univ Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Dept Publ Hlth,Ctr Basic Metab Res, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark

[9] Odense Univ Hosp, Dept Gynecol & Obstet, Sdr Blvd 55, DK-5000 Odense C, Denmark

关键词: Breastfeeding;    Hypertension;    Cardiovascular disease;    Maternal;    Pregnancy;    Obesity;    Abdominal adiposity;   

DOI  :  10.1016/j.ypmed.2018.06.014

来源: Elsevier

【 摘 要 】

In this study, we examined how any, full, and partial breastfeeding durations were associated with maternal risk of hypertension and cardiovascular disease (CVD), and how prepregnancy body mass index (BMI) and waist circumference 7 years postpartum influenced these associations. A total of 63,260 women with live-born singleton infants in the Danish National Birth Cohort (1996-2002) were included. Interviews during pregnancy and 6 and 18 months postpartum provided information on prepregnancy weight, height, and the duration of full and partial breastfeeding. Waist circumference was self-reported 7 years postpartum. Cox regression models were used to estimate hazard ratios of incident hypertension and CVD, registered in the National Patient Register from either 18 months or 7years postpartum through 15 years postpartum. Any breastfeeding <= 4 months was associated with 20-30% lower risks of hypertension and CVD compared to < 4 months in both normal/underweight and overweight/obese women. At follow-up starting 7 years postpartum, similar risk reductions were observed after accounting for waist circumference adjusted for BMI. Partial breastfeeding > 2 months compared to >= 2 months, following up to 6 months of full breastfeeding, was associated with 10-25% lower risk of hypertension and CVD. Compared with short breastfeeding duration, additional partial breastfeeding was as important as additional full breastfeeding in reducing risk of hypertension and CVD. Altogether, longer duration of breastfeeding was associated with lower maternal risk of hypertension and CVD irrespective of prepregnancy BMI and abdominal adiposity 7 years after delivery. Both full and partial breastfeeding contributed to an improved cardiovascular health in mothers.

【 授权许可】

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