Region-specific alteration in brain glutamate: Possible relationship to risk-taking behavior

PHYSIOLOGY & BEHAVIOR

卷:99

Article

Cortese, Bernadette M.¹  Mitchell, Todd R.²  Galloway, Matthew P.^3,4  Prevost, Kristen E.³  Fang, Jidong⁵  Moore, Gregory J.^5,6  Uhde, Thomas W.¹ 

[1] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA

[2] Univ Illinois, Coll Med Peoria, Dept Emergency Med, Peoria, IL 61637 USA

[3] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA

[4] Wayne State Univ, Sch Med, Dept Anesthesia, Detroit, MI 48201 USA

[5] Penn State Univ, Coll Med, Dept Psychiat, Hershey, PA 17033 USA

[6] Penn State Univ, Coll Med, Dept Radiol, Hershey, PA 17033 USA

关键词: Glutamate;    Risk taking;    Anxiety;    Fear;    Posttraumatic stress disorder (PTSD);    Sleep deprivation;    Rats;    Elevated plus maze;    Cortico-limbic circuit;    Medial prefrontal cortex;    Hippocampus;    Amygdala;    Thalamus;    High resolution-magic angle spinning proton magnetic resonance spectroscopy (HR-MAS. H-1 MRS);   

DOI  :  10.1016/j.physbeh.2009.12.005

来源: Elsevier

【 摘 要 】

Risk-taking behaviors involve increased motor activity and reduced anxiety in humans. Total sleep deprivation (SD) in animals produces a similar change in motor and fear behaviors. Investigators studied region-specific brain levels of glutamate in rats after TSD, an animal model of risk-taking behavior. We investigated the effects of sleep deprivation on these behaviors and associated levels of brain glutamate. Compared to the controls, the sleep-deprived rats spent a significantly greater percentage of time in the open arms of the elevated plus maze (EPM), demonstrating reduced fear-like and increased risk-taking behaviors. Additionally, sleep deprivation was associated with a significant increase in glutamate levels in the hippocampus and thalamus. An inverse relationship between glutamate in the medial prefrontal cortex and risk taking in the EPM and a positive association between the ratio of glutamate in the hippocampus to medial prefrontal cortex and risk taking was revealed. The role of sleep deprivation-induced changes in brain glutamate and its relationship to anxiety, fear, and posttraumatic stress disorder (PTSD) is discussed. (C) 2009 Published by Elsevier Inc.

【 授权许可】

Free