Glutamatergic fast-spiking parvalbumin neurons in the lateral hypothalamus: Electrophysiological properties to behavior

PHYSIOLOGY & BEHAVIOR

卷:221

Article; Proceedings Paper

Siemian, Justin N.¹  Sarsfield, Sarah¹  Aponte, Yeka^1,2 

[1] Natl Inst Drug Abuse, Neuronal Circuits & Behav Unit, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Sch Med, Baltimore, MD 21205 USA

关键词: Parvalbumin;    Fast-spiking;    Glutamatergic;    Lateral hypothalamus;    Nociception;    Survival behaviors;   

DOI  :  10.1016/j.physbeh.2020.112912

来源: Elsevier

【 摘 要 】

Throughout the central nervous system, neurons expressing the calcium-binding protein parvalbumin have been typically classified as GABAergic with fast-spiking characteristics. However, new methods that allow systematic characterization of the cytoarchitectural organization, connectivity, activity patterns, neurotransmitter nature, and function of genetically-distinct cell types have revealed populations of parvalbumin-positive neurons that are glutamatergic. Remarkably, such findings challenge longstanding concepts that fast-spiking neurons are exclusively GABAergic, suggesting conservation of the fast-spiking phenotype across at least two neurotransmitter systems. This review focuses on the recent advancements that have begun to reveal the functional roles of lateral hypothalamic parvalbumin-positive neurons in regulating behaviors essential for survival.

【 授权许可】

Free