HEPATIC VAGOTOMY DOES NOT DISRUPT THE NORMAL SATIATION OF NACL APPETITE

PHYSIOLOGY & BEHAVIOR

卷:53

Article

关键词: SODIUM DEPLETION;    SALT APPETITE;    SATIETY;    GASTRIC EMPTYING;    VAGAL AFFERENTS;   

DOI  :  10.1016/0031-9384(93)90214-Z

来源: Elsevier

【 摘 要 】

The necessity of the hepatic branch of the vagus nerve for the normal satiation of NaCl intake under the condition of sodium depletion was tested. Sham- or hepatic-vagotomized male, Long-Evans rats were sodium depleted by injection with Lasix (furosemide, 10 mg) and were maintained overnight on sodium-deficient dict and water. The intake of 0.3 M NaCl during a 2-h salt appetite test was not significantly different between the sham- and hepatic-vagotomized groups. In a second group of sham- or hepatic-vagotomized rats, a load of 7.5 ml of 0.5 M NaCl was given by gavage at 15 or 90 min prior to a 1-h NaCl appetite test. The preload decreased NaCl intake equivalently in both groups. Gastric emptying of a preload of NaCl at 15 and 90 min was also the same for sham- and hepatic-vagotomized rats. Thus, the hepatic branch of the vagus nerve is not necessary for the normal short-term satiation of NaCl intake under the condition of acute sodium depletion produced by furosemide.

【 授权许可】

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