Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people

PHYSIOLOGY & BEHAVIOR

卷:201

Article

de Oliveira, Ardo Belitardo¹  de Mello, Marco Tulio²  Tufik, Serio³  Prieto Peres, Mario Fernando^4,5 

[1] Univ Fed Sao Paulo, Dept Neurol & Neurosurg, 669 Pedro Toledo, BR-04039032 Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Dept Sports Sci, 6627 Pres Antonio Carlos Av, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Sao Paulo, Dept Psychobiol, 862 Botucatu, BR-04032030 Sao Paulo, SP, Brazil

[4] Albert Einstein Israeli Hosp, Brain Inst, 627-701 Ave Albert Einstein, BR-05652900 Sao Paulo, Brazil

[5] Univ Sao Paulo, Med Sch, Psychiat Inst, 785 Rua Dr Ovidio Pires Campos, BR-05403903 Sao Paulo, SP, Brazil

关键词: Endocannabinoids;    Weight loss;    Physical activity;    Exercise;    Mental Health;    Peak Oxygen Uptake;   

DOI  :  10.1016/j.physbeh.2018.12.018

来源: Elsevier

【 摘 要 】

Anandamide, a major endocannabinoid, participates in energy metabolism homeostasis and neurobehavioral processes. In a secondary analysis of an open-label, randomized controlled trial, we investigated the long-term effect of aerobic exercise on resting plasma anandamide, and explored its relationship with changes in body weight, cardiorespiratory fitness, and mood status in healthy, physically inactive individuals. Participants recruited between March 2013 to August 2015 at the UNIFESP's Neurology/Psychobiology Department were randomly allocated into a 12-weeks supervised moderate exercise program, or into waitlist, control condition. Thirty-four participants (age = 38 +/- 11.5, BMI = 26.6 +/- 3.6) were intention to treat-analysed (Exercise: n = 17; Control: n = 17). After intervention, there were significant decreases in plasma anandamide (p < .01), anger, anxiety, and body weight (all p < .05), whereas cardiorespiratory fitness increased (p < .05) in the exercise group. There were no significant changes in any variable for the control group. In the whole cohort, adjusted R-2 of multiple linear regressions showed that 12.2% of change body weight was explained by changes in anandamide (beta = 0.391, p = .033), while 27% of change in mood disturbance (beta= 0. 546, p = .003), and 13.1% of change in anger (beta = 0.404, p = .03) was explained by changes in anandamide. Our data suggest that the weight loss and mood improvement through regular moderate exercise may involve changes in anandamide metabolism/signaling.

【 授权许可】

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