Neurobiology of hyperactivity and reward: Agreeable restlessness in Anorexia Nervosa

PHYSIOLOGY & BEHAVIOR

卷:100

Article; Proceedings Paper

Scheurink, Anton J. W.¹  Boersma, Gretha J.¹  Nergardh, Ricard²  Sodersten, Per^3,4 

[1] Univ Groningen, Dept Neuroendocrinol, NL-9750 AA Haren, Netherlands

[2] Karolinska Inst, Dept Pediat, S-14186 Huddinge, Sweden

[3] Karolinska Inst, Sect Appl Neuroendocrinol, Mandometer Clin, S-14104 Huddinge, Sweden

[4] Karolinska Inst, Sect Appl Neuroendocrinol, Mandolean Clin, S-14104 Huddinge, Sweden

关键词: Dopamine;    Orexin;    Food anticipatory activity;    Activity based anorexia;   

DOI  :  10.1016/j.physbeh.2010.03.016

来源: Elsevier

【 摘 要 】

Restricted food intake is associated with increased physical activity, very likely an evolutionary advantage, initially both functional and rewarding. The hyperactivity of patients with Anorexia Nervosa, however, is a main problem for recovery. This seemingly paradoxical reward of hyperactivity in Anorexia Nervosa is one of the main aspects in our framework for the neurobiological changes that may underlie the development of the disorder. Here, we focus on the neurobiological basis of hyperactivity and reward in both animals and humans suggesting that the mesolimbic dopamine and hypothalamic orexin neurons play central roles. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. (C) 2010 Elsevier Inc. All rights reserved.

【 授权许可】

Free