From fat fruit fly to human obesity

PHYSIOLOGY & BEHAVIOR

卷:136

Review

Smith, Wanli W.¹  Thomas, Joseph¹  Liu, Jingnan¹  Li, Tianxia¹  Moran, Timothy H.² 

[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[2] Johns Hopkins Univ, Dept Psychiat, Sch Med, Baltimore, MD 21287 USA

关键词: Obesity;    Drosophila melanogaster;    Metabolic homeostasis;    Feeding behavior;    Genetic tools;    Fat deposition;   

DOI  :  10.1016/j.physbeh.2014.01.017

来源: Elsevier

【 摘 要 】

Obesity is a chronic metabolic disease that has become a global problem. Although a tremendous amount of effort has been spent to prevent and treat obesity, its etiology is still largely unknown and there are not yet sufficient strategies to control obesity. Recently, the fruit fly, Drosophila melanogaster, has become a useful model for studying metabolic homeostasis and obesity related disorders. The goal of this mini-review is to summarize the recent achievements of Drosophila models and to highlight the experimental protocols used in studying feeding behavior and energy homeostasis in the fly. The Drosophila models provide useful tools to understand obesity pathogenesis and to develop novel therapeutics. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free