Effects of sleep restriction during pregnancy on the mother and fetuses in rats

PHYSIOLOGY & BEHAVIOR

卷:155

Article

Espinoza Pardo, Grace Violeta¹  Goularte, Jeferson Ferraz¹  Hoefel, Ana Lucia¹  de Castro, Alexandre Luz¹  Kucharski, Luiz Carlos¹  da Rosa Araujo, Alex Sander¹  Lucion, Aldo Bolten¹ 

[1] Univ Fed Rio Grande Sul UFRGS, Dept Fisiol, Inst Ciencias Basicas Saude ICBS, Rua Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil

关键词: Maternal behavior;    BDNF;    ROS;    Prolactin;    Oxytocin;    Corticosterone;   

DOI  :  10.1016/j.physbeh.2015.11.037

来源: Elsevier

【 摘 要 】

The present study aimed to analyze the effects of sleep restriction (SR) during pregnancy in rats. The following three groups were studied: home cage (HC pregnant females remained in their home cage), Sham (females were placed in tanks similar to the SR group but with sawdust) and SR (females were submitted to the multiple platform method for 20 h per day from gestational days (GD) 14 to 20). Plasma corticosterone after 6 days of SR was not different among the groups. However, the relative adrenal weight was higher in the SR group compared with the HC group, which suggests possible stress impact SR during pregnancy reduces the body weight of the female but no changes in liver glycogen, cholesterol and triglycerides, and muscle glycogen were detected. On GD 20, the fetuses of the females submitted to SR exhibited increased brain derived neurotrophic factor (BDNF) in the hippocampus, which indicates that sleep restriction of mothers during the final week of gestation may affect neuronal growth factors in a fetal brain structure, in which active neurogenesis occurs during the deprivation period. However, no changes in the total reactive oxygen species (ROS) in the cortex, hippocampus, or cerebellum of the fetuses were detected. SR females showed no major change in the maternal behavior, and the pups' preference for the mother's odor on postpartum day (PPD) 7 was not altered. On GD 20, the SR females exhibited increased plasma prolactin (PRL) and oxytocin (OT) compared with the HC and Sham groups. The negative outcomes of sleep restriction during delivery could be related, in part, to this hormonal imbalance. Sleep restriction during pregnancy induces different changes compared with the changes described in males and affects both the mother and offspring. (C) 2015 Elsevier Inc. All rights reserved.

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