Macronutrient choice of BTBR.NZW mice congenic for a 21-gene region of chromosome 17

PHYSIOLOGY & BEHAVIOR

卷:106

Article

Tordoff, Michael G.¹  Jaji, Samira A.¹  Marks, Jacob M.¹  Ellis, Hillary T.¹ 

[1] Monell Chem Senses Ctr, Philadelphia, PA 19104 USA

关键词: Carbohydrate intake;    Fat intake;    Diet selection;    Taste preferences;   

DOI  :  10.1016/j.physbeh.2012.03.030

来源: Elsevier

【 摘 要 】

There has been scant work to investigate the mechanisms influencing macronutrient selection by mice. Here, we measured the consumption and choice of carbohydrate- and fat-containing diets by NZW/LacJ (NZW) and BTBR/T+ tf/J (BTBR) strains. We found that NZW mice voluntarily ate more carbohydrate and less fat than did BTBR mice. Mice with a BTBR background and a heterozygous (BTBR/NZW) congenic region on chromosome 17 between 25.7 and 27.5 Mb (N-10 generation) or 26.7 and 27.5 Mb (N-12 generation) also ate more carbohydrate and less fat than did homozygous (BTBR/BTBR) littermate controls. Of the 21 known and. predicted genes in the congenic interval between 26.7 and 27.5 Mb, we raise for consideration as a causative candidate Itpr3, the inositol triphosphate receptor type 3 gene, which is a component of the GPCR-mediated taste transduction cascade. We speculate that a mutation in Itpr3 influences food choice by impairing the detection of nutrients in the macronutrient-containing diets. (C) 2012 Elsevier Inc. All rights reserved.

【 授权许可】

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