ENDOTOXIN TREATMENT OF PREGNANT RATS AFFECTS SEXUAL-BEHAVIOR OF THE MALE OFFSPRING

PHYSIOLOGY & BEHAVIOR

卷:49

Note

WIJKSTRA, S ; VALKHOF, N ; KOOLHAAS, JM ; SCHUILING, GA

关键词: RAT;    PREGNANCY;    ENDOTOXIN;    PLACENTAL DAMAGE;    OFFSPRING;    MAZE TEST;    SEXUAL BEHAVIOR;   

DOI  :  10.1016/0031-9384(91)90294-X

来源: Elsevier

【 摘 要 】

The offspring of endotoxin-infused pregnant rats (0.2-mu-g endotoxin, 53.3 min, day 18 of pregnancy) did not exhibit different behavior in the Hebb-Williams-type maze test, but the males showed aberrations in the sexual behavior test. Because endotoxin did not cross the placental barrier, it was concluded that the effect reflects abnormal brain development, caused by endotoxin-induced placental malfunction, notably impaired oxygen transport.

【 授权许可】

Free