Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism

PHYSIOLOGY & BEHAVIOR

卷:152

Article; Proceedings Paper

Burke, Mary V.^1,2  Small, Dana M.^1,2,3,4,5 

[1] Yale Univ, Sch Med, Yale Interdept Neurosci Program, New Haven, CT USA

[2] John B Pierce Fdn Lab, New Haven, CT 06519 USA

[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[4] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

[5] Univ Cologne, Ctr Excellence, D-50931 Cologne, Germany

关键词: Non-nutritive sweeteners;    Feeding;    Obesity;    Metabolism;    Body weight;    Taste perception;    Energy balance;    Sweetening agents;    Gut;    Brain;   

DOI  :  10.1016/j.physbeh.2015.05.036

来源: Elsevier

【 摘 要 】

Evidence linking sugar-sweetened beverage (SSB) consumption to weight gain and other negative health outcomes has prompted many individuals to resort to artificial, non-nutritive sweetener (NNS) substitutes as a means of reducing SSB intake. However, there is a great deal of controversy regarding the biological consequences of NNS use, with accumulating evidence suggesting that NNS consumption may influence feeding and metabolism via a variety of peripheral and central mechanisms. Here we argue that NNSs are not physiologically inert compounds and consider the potential biological mechanisms by which NNS consumption may impact energy balance and metabolic function, including actions on oral and extra-oral sweet taste receptors, and effects on metabolic hormone secretion, cognitive processes (e.g. reward learning, memory, and taste perception), and gut microbiota. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free