PLACENTAL OPIOID-ENHANCING FACTOR (POEF) - GENERALIZABILITY OF EFFECTS

PHYSIOLOGY & BEHAVIOR

卷:50

Article

ABBOTT, P ; THOMPSON, AC ; FERGUSON, EJ ; DOERR, JC ; TARAPACKI, JA ; KOSTYNIAK, PJ ; SYRACUSE, JA ; CARTONIA, DM ; KRISTAL, MB

关键词: POEF;    PLACENTA;    AMNIOTIC FLUID;    PLACENTOPHAGIA;    ANALGESIA;    PAIN;    HYPERTHERMIA;    RAT;    HUMAN DOLPHIN;    PARTURITION;    AFTERBIRTH;    OPIOIDS;    MORPHINE;    VSIA;   

DOI  :  10.1016/0031-9384(91)90417-M

来源: Elsevier

【 摘 要 】

A substance in amniotic fluid and placenta (POEF for Placental Opioid-Enhancing Factor) has been shown to enhance opiate- or opioid-mediated analgesia in rats. Recent studies have only touched on the generalizability of the phenomenon. The present studies further tested the generalizability of the POEF effect: they examined sex specificity of the mechanism; whether POEF activity exists in afterbirth material of species other than the rat; whether POEF activity exists in tissue other than afterbirth material; whether POEF activity could be demonstrated after injection rather than ingestion of afterbirth material; and whether POEF enhances all opioid-mediated phenomena. We found that (a) POEF is effective in male rats as well as in female rats; (b) POEF activity exists in human and dolphin afterbirth material; (c) ingestion of pregnant-rat liver does not produce enhancement of opioid-mediated analgesia; (d) POEF does not seem to be effective when amniotic fluid is injected either IP or SC; and (e) POEF does not modify morphine-induced hyperthermia.

【 授权许可】

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