Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED)

PHYSIOLOGY & BEHAVIOR

卷:94

Article; Proceedings Paper

Geliebter, Allan^1,2,3  Hashim, Sami A.¹  Gluck, Mard E.⁴ 

[1] St Lukes Roosevelt Hosp, Dept Med, NY Obes Res Center, New York, NY 10025 USA

[2] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10027 USA

[3] Touro Coll, New York, NY 10010 USA

[4] NIDDKD, Obes & Diabet Clin Res Sect, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ 85016 USA

关键词: obesity;    food intake;    eating disorders;    treatment;    cognitive behavior therapy;    CBT;    nutrition;   

DOI  :  10.1016/j.physbeh.2008.04.013

来源: Elsevier

【 摘 要 】

BED is characterized by overeating with a loss of control. The primary aim of the study was to measure plasma concentrations of three key gut peptides influencing hunger (ghrelin) and satiety (PYY, GLP-1) to ascertain potential abnormalities in BED. The participants were 10 obese BED and 9 obese nonBED premenopausal women. They did not differ in age, 30.1 +/- 8.1 SD, BMI, 36.2 +/- 5.9, or % body fat, 43.3+/-5.7. Following a13-h overnight fast, blood was drawn (-15, 0, 5,15, 30, 60,90,120 min) for measurement of total plasma concentrations of ghrelin, PYY and GLP-1, pre and post ingestion of a nutritionally complete liquid meal (1256 kJ) at 9 am (0-5 min). Ratings of hunger and fullness preceded each blood draw. Ghrelin was significantly lower premeal at -15 min (P=.05) and postmeal at 90 min (P=.027) and 120 min (P=.025) in the BED group as compared to the nonBED group. Ghrelin also declined less postprandially in the BED group (P=.019) with a longer time to the nadir value (P=.004). However, fasting and meal-related changes in levels of PYY and GLP-1 did not differ between the groups nor did ratings of hunger and fullness. Following a randomized cognitive behavior and dietary intervention, the ghrelin values in BED normalized. Prior to treatment, the lower fasting ghrelin in BED may be a consequence of down regulation by overeating. The lack of differences in the satiety promoting hormones, PYY and GLP-1, makes them unlikely contributors to the binge eating in BED. (C) 2008 Elsevier Inc. All rights reserved.

【 授权许可】

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