Brain mineralocorticoid receptor function in control of salt balance and stress-adaptation

PHYSIOLOGY & BEHAVIOR

卷:178

Review

de Kloet, Edo Ronald¹  Joels, Marian^2,3 

[1] Leiden Univ, Med Ctr, Dept Med, Div Endocrinol, Leiden, Netherlands

[2] Univ Med Ctr Utrecht, Dept Translat Neurosci, Brain Ctr Rudolf Magnus, Utrecht, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands

关键词: Stress;    Salt appetite;    Brain;    Cortisol;    Corticosterone;    Aldosterone;    Mineralocorticoid receptors;    Glucocorticoid receptors;   

DOI  :  10.1016/j.physbeh.2016.12.045

来源: Elsevier

【 摘 要 】

We will highlight in honor of Randall Sakai the peculiar characteristics of the brain mineralocorticoid receptor (MR) in its response pattern to the classical mineralocorticoid aldosterone and the naturally occurring glucocorticoids corticosterone and cortisol. Neurons in the nucleus tractus solitarii (NTS) and circumventricular organs express MR, which mediate selectively the action of aldosterone on salt appetite, sympathetic outflow and volume regulation. The MR-containing NTS neurons innervate limbic-forebrain circuits enabling aldosterone to also modulate reciprocally arousal, motivation, fear and reward. MR expressed in abundance in this limbic-forebrain circuitry, is target of cortisol and corticosterone in modulation of appraisal processes, memory performance and selection of coping strategy. Complementary to this role of limbic MR is the action mediated by the lower affinity glucocorticoid receptors (GR), which promote subsequently memory storage of the experience and facilitate behavioral adaptation. Current evidence supports the hypothesis that an imbalance between MR-and GR-mediated actions compromises resilience and adaptation to stress. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

Free