Cyclic AMP tastes aversive, not sweet, to rats

PHYSIOLOGY & BEHAVIOR

卷:59

Article

Houpt, TA ; Frankmann, SP ; Berlin, R

关键词: 8cpt-cAMP;    saccharin;    sucrose;    second messenger;    lickometer;    licking;   

DOI  :  10.1016/0031-9384(95)02090-X

来源: Elsevier

【 摘 要 】

Electrophysiological and biochemical evidence suggests that cAMP mediates sweet taste transduction. Neural recordings from anesthetized rats and in vitro preparations demonstrate that membrane-permeable cAMP analogues mimic the effects of sucrose and artificial sweetners. We presented solutions of sodium 8-(4-chlorophenylthio)-adenosine 3'-5'-cyclic monophosphate (8cpt-cAMP), a water-soluble, membrane-permeable cAMP analogue to freely behaving rats in short-term lickometer tests. Rats licked significantly less to 8cpt-cAMP than to sucrose or palatable saccharin solutions. Rats could taste 8cpt-cAMP solutions, however, because they licked less to 8cpt-cAMP in mixture with sucrose than to sucrose alone. Because 8cpt-cAMP decreased licking when mixed with sucrose, we conclude that the taste of 8cpt-cAMP is aversive, not sweet, to freely behaving rats.

【 授权许可】

Free