Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length

PHYSIOLOGY & BEHAVIOR

卷:106

Article

Tomiyama, A. Janet^1,2,3,4  O'Donovan, Aoife^5,6  Lin, Jue⁷  Puterman, Eli⁵  Lazaro, Alanie⁵  Chan, Jessica⁵  Dhabhar, Firdaus S.⁸  Wolkowitz, Owen⁵  Kirschbaum, Clemens⁹  Blackburn, Elizabeth⁷  Epel, Elissa⁵ 

[1] Rutgers State Univ, Dept Psychol, Piscataway, NJ 08855 USA

[2] Rutgers State Univ, Dept Nutr Sci, Piscataway, NJ 08855 USA

[3] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging, Piscataway, NJ 08855 USA

[4] Rutgers State Univ, NJ Inst Food Nutr & Hlth, Piscataway, NJ 08855 USA

[5] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[6] Vet Affairs Med Ctr, San Francisco, CA 94121 USA

[7] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[8] Stanford Univ, Dept Psychiat & Behav Sci, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA

[9] Tech Univ Dresden, Dept Psychol, Dresden, Germany

关键词: Cortisol;    Allostasis;    Allostatic load;    Telomere;    Cellular aging;    Stress;    HPA axis;   

DOI  :  10.1016/j.physbeh.2011.11.016

来源: Elsevier

【 摘 要 】

Long-term exposure to stress and its physiological mediators, in particular cortisol, may lead to impaired telomere maintenance. In this study, we examine if greater cortisol responses to an acute stressor and/or dysregulated patterns of daily cortisol secretion are associated with shorter telomere length. Twenty-three postmenopausal women comprising caregivers for dementia partners (n = 14) and age- and BMI-matched noncaregivers provided home sampling of cortisol-saliva samples at waking, 30 min after waking, and bedtime, and a 12-hour overnight urine collection. They were also exposed to an acute laboratory stressor throughout which they provided saliva samples. Peripheral blood mononuclear cells were isolated from a fasting blood sample and assayed for telomere length. As hypothesized, greater cortisol responses to the acute stressor were associated with shorter telomeres, as were higher overnight urinary free cortisol levels and flatter daytime cortisol slopes. While robust physiological responses to acute stress serve important functions, the longterm consequences of frequent high stress reactivity may include accelerated telomere shortening. (C) 2011 Elsevier Inc. All rights reserved.

【 授权许可】

Free