Adaptation of lipid-induced satiation is not dependent on caloric density in rats

PHYSIOLOGY & BEHAVIOR

卷:93

Article

Paulino, G.^1,2  Darcel, N.^1,2  Tome, D.²  Raybould, H.¹ 

[1] Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA

[2] INRA, Agroparistech, UMR Nutr Physiol & Ingest Behav 914, Paris, France

关键词: high fat;    meal pattern analysis;    satiation;    diet adaptation;    food intake;   

DOI  :  10.1016/j.physbeh.2007.12.015

来源: Elsevier

【 摘 要 】

Food intake is modulated by ingestive (gastrointestinal) and post-ingestive signals; ingested fat is potent to produce short-term satiety (satiation) but this can be modified by long-term ingestion of a high fat diet. Aim: Determine whether altered lipid-induced satiation is dependent on the fat content of the diet, rather than increased caloric density or changes in adiposity. Methods: Initial experiments deter-mined the differences in the microstructure of meal patterns in rats fed a high fat diet (HF: 38% fat kcal) and in rats pair-fed an isocaloric, isonitrogenous low fat diet (LF: 10% fat kcal) and changes in meal patterns measured after long-term maintenance on the HF diet. Results: Rats fed the HF diet had a significant 50% increase in meal frequency compared to rats fed the LF diet; in addition, there was a significant reduction in meal size (32%) and inter meal interval (38%) consistent with induction of satiation. After 8 weeks on the HF diet, these parameters tend to approach those of rats maintained on the LF diet. There was a significant 56% decrease in the activation of neurons in the NTS in response to intragastric gavage of lipid in rats maintained for 8 weeks on the HE compared to LF diet. Conclusion: Dietary fat alters meal patterns consistent with induction of a short-term satiety signal. This signal is attenuated with long-term exposure to dietary lipid, in the absence of ingestion of additional calories or changes in body weight. This adaptation of short-term satiety might contribute to diet-induced obesity. (C) 2008 Elsevier Inc. All rights reserved.

【 授权许可】

Free