An expanded view of energy homeostasis: Neural integration of metabolic, cognitive, and emotional drives to eat

PHYSIOLOGY & BEHAVIOR

卷:97

Article; Proceedings Paper

Shin, Andrew C.¹  Zheng, Huiyuan¹  Berthoud, Hans-Rudolf¹ 

[1] Pennington Biomed Res Ctr, Neurobiol Nutr Lab, Louisiana State Univ Syst, Baton Rouge, LA 70808 USA

关键词: Appetite;    Obesity;    Hypothalamus;    Food reward;    Food hedonics;    Motivation;    Gut hormones;   

DOI  :  10.1016/j.physbeh.2009.02.010

来源: Elsevier

【 摘 要 】

The traditional view of neural regulation of body energy homeostasis focuses on internal feedback signals integrated in the hypothalamus and brainstem and in turn leading to balanced activation of behavioral, autonomic, and endocrine effector pathways leading to changes in food intake and energy expenditure. Recent observations have demonstrated that many of these internal signals encoding energy status have much wider effects on the brain, particularly sensory and cortico-limbic systems that process information from the outside world by detecting and interpreting food cues, forming, storing, and recalling representations of experience with food, and assigning hedonic and motivational value to conditioned and unconditioned food stimuli. Thus, part of the metabolic feedback from the internal milieu regulates food intake and energy balance by acting on extra hypothalamic structures, leading to an expanded view of neural control of energy homeostasis taking into account the need to adapt to changing conditions in the environment. The realization that metabolic signals act directly on these non-traditional targets of body energy homeostasis brings opportunities for novel drug targets for the fight against obesity and eating disorders. (C) 2009 Elsevier Inc. All rights reserved.

【 授权许可】

Free