Effects of sugar solutions on hypothalamic appetite regulation

PHYSIOLOGY & BEHAVIOR

卷:139

Article

Colley, Danielle L.¹  Castonguay, Thomas W.¹ 

[1] Univ Maryland, Dept Nutr & Food Sci, College Pk, MD 20742 USA

关键词: Food intake;    Fructose;    High fructose corn syrup;    Glucose;    Sucrose;    Obesity;   

DOI  :  10.1016/j.physbeh.2014.11.025

来源: Elsevier

【 摘 要 】

Several hypotheses for the causes of the obesity epidemic in the US have been proposed. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine if different sugars might promote changes in the hypothalamic mechanisms controlling food intake by measuring several hypothalamic peptides subsequent to overnight access to dilute glucose, sucrose, high fructose corn syrup, or fructose solutions. Rats were given access to food, water and a sugar solution for 24 h, after which blood and tissues were collected. Fructose access (as opposed to other sugars that were tested) resulted in a doubling of circulating triglycerides. Glucose consumption resulted in upregulation of 7 satiety-related hypothalamic peptides whereas changes in gene expression were mixed for remaining sugars. Also, following multiple verification assays, 6 satiety related peptides were verified as being affected by sugar intake. These data provide evidence that not all sugars are equally effective in affecting the control of intake. (C) 2014 Published by Elsevier Inc.

【 授权许可】

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