Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma

MARINE POLLUTION BULLETIN

卷:101

Article

Hong, Haizheng^1,2,3  Shen, Rong¹  Liu, Wanxin³  Li, Dongmei¹  Huang, Lingming³  Shi, Dalin^1,2,3 

[1] Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen 361102, Fujian, Peoples R China

[2] Xiamen Univ, Key Lab Minist Educ Coastal & Wetland Ecosyst, Xiamen 361102, Peoples R China

[3] Xiamen Univ, Coll Environm & Ecol, Xiamen 361102, Peoples R China

关键词: Hexabromocyclododecanes;    Diastereoisomers;    Oryzias melastigma;    Oxidative stress;    Developmental toxicity;   

DOI  :  10.1016/j.marpolbul.2015.11.009

来源: Elsevier

【 摘 要 】

The composition of major hexabromocyclododecane (HBCD) diastereoisomers, i.e. alpha-, beta-, and gamma-HBCDs, in marine biota is different from that of the commercially available form (technical HBCD), which is used extensively for toxicological studies. To properly evaluate the impact of HBCDs, the embryos of Oryzias melastigma were used to examine the developmental toxicity of the individual diastereoisomers. Results showed that HBCD diastereoisomers at the environmentally realistic concentrations in the embryos induced malformation rate and heartbeat, and caused the appearance of apoptotic heart. In addition, alpha-, beta-, and gamma-HBCDs had similar potency to stimulate the generation of reactive oxygen species, consequently leading to apoptosis in O. melastigma embryos. The order of the developmental toxicity of alpha-, beta-, and gamma-HBCDs in O. melastigma embryos was different from that in zebrafish embryos studied previously, which highlighted the importance of using species from both fresh and salt water for toxicity assessment. (C) 2015 Elsevier Ltd. All rights reserved.

【 授权许可】

Free