Cortical structural abnormalities in deficit versus nondeficit schizophrenia

SCHIZOPHRENIA RESEARCH

卷:136

Article

Fischer, Bernard A.^1,2  Keller, William R.¹  Arango, Celso³  Pearlson, Godfrey D.⁴  McMahon, Robert P.¹  Meyer, Walter A.¹  Francis, Alan⁵  Kirkpatrick, Brian⁶  Carpenter, William T.^1,2  Buchanan, Robert W.¹ 

[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Catonsville, MD 21228 USA

[2] Mental Illness Res Educ & Clin Ctr MIRECC, Vet Affairs Capital Network VISN 5, Baltimore, MD USA

[3] Hosp Gen Univ Gregorio Maranon, Dept Psiquiatria, CIBERSAM, Madrid, Spain

[4] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[5] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Psychiat, Boston, MA 02215 USA

[6] Texas A&M Hlth Sci Ctr Coll Med, Dept Psychiat & Behav Sci, Temple, TX USA

关键词: Schizophrenia;    Deficit syndrome;    Frontal lobe;    Temporal lobe;    Structural MRI;   

DOI  :  10.1016/j.schres.2012.01.030

来源: Elsevier

【 摘 要 】

Objective: To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia. Method: A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls. Results: The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures. Conclusion: People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

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