A multimodal approach to investigate biomarkers for psychosis in a clinical setting: The integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project

SCHIZOPHRENIA RESEARCH

卷:143

Article

Koike, Shinsuke^1,2  Takano, Yosuke¹  Iwashiro, Norichika¹  Satomura, Yoshihiro¹  Suga, Motomu¹  Nagai, Tatsuya¹  Natsubori, Tatsunobu¹  Tada, Mariko¹  Nishimura, Yukika¹  Yamasaki, Syudo^3,4  Takizawa, Ryu¹  Yahata, Noriaki¹  Araki, Tsuyoshi⁴  Yamasue, Hidenori¹  Kasai, Kiyoto^1,5 

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Div Counseling & Support, Off Mental Hlth Support, Bunkyo Ku, Tokyo 1130033, Japan

[3] Tokyo Metropolitan Inst Med Sci, Dept Psychiat & Behav Sci, Setagaya Ku, Tokyo 1568506, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Youth Mental Hlth, Bunkyo Ku, Tokyo 1138655, Japan

[5] Natl Biosci Database Ctr NBDC, JST, Chiyoda Ku, Tokyo 1020081, Japan

关键词: Schizophrenia;    Neuroimaging;    Biological markers;    Early intervention;    Clinical outcome;   

DOI  :  10.1016/j.schres.2012.11.012

来源: Elsevier

【 摘 要 】

Longitudinal clinical investigations and biological measurements have determined not only progressive brain volumetric and functional changes especially around the onset of psychosis but also the abnormality of developmental pathways based on gene-environment interaction model. However, these studies have contributed little to clinical decisions on their diagnosis and therapeutic choices because of subtle differences between patients and healthy controls. A multi-modal approach may resolve this limitation and is favorable to explore the pathophysiology of psychosis. The integrative neuroimaging studies for schizophrenia targeting early intervention and prevention (IN-STEP) is a research project aimed at exploring the pathophysiological features of the onset of psychosis and investigating possible predictive biomarkers for the clinical treatment of psychosis. Since 2008, we have adopted blood sampling, neurocognitive batteries, neurophysiological assessment, structural imaging, and functional imaging longitudinally for help-seeking ultra-high-risk (UHR) individuals and patients with first-episode psychosis (FEP). Here, we intend to introduce the IN-STEP research study protocol and present preliminary clinical findings. Thirty-seven UHR individuals and 30 patients with FEP participated in this study. Six months later, there was no difference in objective and subjective scores between the groups, which suggests that young people having symptoms and functional deficits should be cared for regardless of their history of psychosis according to their clinical stages. The rate of transition to psychosis was 7.1%, 8.0%, and 35.3% (at 6, 12, and 24 months, respectively). Through this research project, we expect to clarify the pathophysiological features around the onset of psychosis and improve the prognosis of psychosis through clinical application. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

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