The effects of individually tailored formulation-based cognitive behavioural therapy in auditory hallucinations and delusions: A meta-analysis

SCHIZOPHRENIA RESEARCH

卷:156

Article

van der Gaag, Mark^1,2,3  Valmaggia, Lucia R.^4,5  Smit, Filip^1,2,6,7 

[1] Vrije Univ Amsterdam, Dept Clin Psychol, NL-1081 BT Amsterdam, Netherlands

[2] EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

[3] Parnassia Psychiat Inst, Dept Psychiat, The Hague, Netherlands

[4] Kings Coll London, Dept Psychol, Inst Psychiat, London WC2R 2LS, England

[5] South London & Maudsley NHS Fdn Trust, Outreach & Support South London OASIS, London, England

[6] Netherlands Inst Mental Hlth & Addict, Trimbos Inst, Ctr Prevent & Early Intervent, Utrecht, Netherlands

[7] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands

关键词: Schizophrenia;    Delusions;    Hallucinations;    Cognitive behavioural therapy;    Meta-analysis;   

DOI  :  10.1016/j.schres.2014.03.016

来源: Elsevier

【 摘 要 】

There is nometa-analysis of cognitive behavioural therapy for delusions and hallucinations separately. The aim of this meta-analysis is to evaluate the end-of-treatment effects of individually tailored case-formulation cognitive behavioural therapy on delusions and auditory hallucinations using symptom-specific outcome measures. A systematic search of the trial literature was conducted in MEDLINE, PSYCHINFO and EMBASE. Eighteen studies were selected with symptom specific outcome measures. Hedges' g was computed and outcomes were pooled meta-analytically using the random-effects model. Our main analyses were with the selected studies with CBT using individually tailored case-formulation that aimed to reduce hallucinations and delusions. The statistically significant effect-sizes were 0.36 with delusions and 0.44 with hallucinations, which are modest and in line with other recent meta-analyses. Contrasted with active treatment, CBT for delusions lost statistical significance (0.33), but the effect-size for CBT for hallucinations increased (0.49). Blinded studies reduced effect-size in delusions (0.24) and gained some in hallucinations (0.46). There was no heterogeneity in hallucinations and moderate heterogeneity in delusion trials. We conclude that CBT is effective in treating auditory hallucinations. CBT for delusions is also effective, but the results must be interpreted with caution, because of heterogeneity and the non-significant effect-sizes when compared with active treatment. (C) 2014 Elsevier B. V. All rights reserved.

【 授权许可】

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