Associations between spontaneous movement abnormalities and psychotic-like experiences in the general population

SCHIZOPHRENIA RESEARCH

卷:132

Article

Mittal, Vijay A.^1,2  Dean, Derek J.¹  Pelletier, Andrea¹  Caligiuri, Michael³ 

[1] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[2] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

[3] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

关键词: Psychotic-like experiences;    Dyskinesia;    Movement abnormalities;    ADAPT;   

DOI  :  10.1016/j.schres.2011.06.028

来源: Elsevier

【 摘 要 】

An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spontaneous dyskinetic movements are linked to specific pathogenic factors underlying schizophrenia, but to date there has been little research directed towards determining whether these events are associated with PLEs. In this study, 119 individuals were assessed for PLEs and administered with a sensitive instrumental test of upper extremity dyskinesia. Present findings suggest a relationship between subtle dyskinesia and PLEs in the general population, and provide a new perspective of the psychosis continuum by indicating that basal ganglia pathology may also underlie PLEs at the non-clinical end of this spectrum. (C) 2011 Elsevier B.V. All rights reserved.

【 授权许可】

Free