Self-reported sleep disturbances associated with procedural learning impairment in adolescents at ultra-high risk for psychosis

SCHIZOPHRENIA RESEARCH

卷:190

Article

Lunsford-Avery, Jessica R.¹  Dean, Derek J.^2,3  Mittal, Vijay A.⁴ 

[1] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, 2608 Erwin Rd Suite 300, Durham, NC 27705 USA

[2] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[3] Univ Colorado, Ctr Neurosci, Boulder, CO 80309 USA

[4] Northwestern Univ, Dept Psychol, Evanston, IL USA

关键词: Psychosis;    Schizophrenia;    Ultra high-risk;    Prodromal;    Sleep;    Procedural learning;   

DOI  :  10.1016/j.schres.2017.03.025

来源: Elsevier

【 摘 要 】

Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N = 62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased self-reported problemswith sleep latency, efficiency, and qualitywere associatedwith impaired procedural learning rate. Further, within-sample comparisons revealed that UHR youth reporting better sleep displayed a steeper learning curve than those with poorer sleep. Sleep disturbances appear to contribute to cognitive/motor deficits in the UHR period and may play a role in psychosis etiology. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free