P300 as an index of transition to psychosis and of remission: Data from a clinical high risk for psychosis study and review of literature

SCHIZOPHRENIA RESEARCH

卷:226

Review

Tang, Yingying^1,2  Wang, Junjie^1,3  Zhang, Tianhong¹  Xu, Lihua¹  Qian, Zhenying¹  Cui, Huiru¹  Tang, Xiaochen¹  Li, Huijun⁴  Whitfield-Gabrieli, Susan⁵  Shenton, Martha E.^6,7  Seidman, Larry J.⁸  McCarley, Robert W.⁹  Keshavan, Matcheri S.⁸  Stone, William S.⁸  Wang, Jijun^1,10,11  Niznikiewicz, Margaret A.⁹ 

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Psychot Disorders, Shanghai Mental Hlth Ctr, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China

[2] Tongji Univ, Minist Educ, Key Lab Embedded Syst & Serv Comp, Shanghai 201804, Peoples R China

[3] Soochow Univ, Affiliated Guangji Hosp, Inst Mental Hlth, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China

[4] Florida A&M Univ, Dept Psychol, Tallahassee, FL USA

[5] MIT, McGovern Inst Brain Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[6] Harvard Med Sch, Dept Psychiat, Psychiat Neuroimaging Lab, Brigham & Womens Hosp, Boston, MA 02130 USA

[7] Vet Affairs Boston Healthcare Syst, Res & Dev, Brockton Div, Brockton, MA USA

[8] Harvard Med Sch, Dept Psychiat, Beth Israel Deaconess Med Ctr, Boston, MA 02130 USA

[9] Harvard Med Sch, Dept Psychiat, Vet Adm Med Ctr, Boston, MA 02130 USA

[10] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China

[11] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China

关键词: Clinical high risk for psychosis;    P300 novel;    P300 oddball;    Transition to psychosis;    Remission from psychotic symptoms;   

DOI  :  10.1016/j.schres.2019.02.014

来源: Elsevier

【 摘 要 】

Auditory P300 oddball and novel components index working memory operations and salience processing, respectively, and are regarded as biomarkers of neurocognitive changes in both chronic and first-episode schizophrenia. Much less is known about whether P300 abnormalities exist in individuals at clinical high risk for psychosis (CHR) and if they are predictors of both transition to psychosis and remission from symptoms. One hundred and four CHR and 69 healthy control individuals (HC) completed P300 oddball paradigm, and 131 CHR and 69 HC subjects completed P300 novel paradigm. All CHR subjects were followed up for one year and stratified into CHR converters (CHR\\C) and non-converters (CHR-NC), with CHR-NC further stratified into remitted and non-remitted subgroups. Between-group comparisons of P300 oddball and novel amplitude and latency were performed among CHR\\C, CHR-NC and HC, as well as among CHR\\C, non-remitted CHR, remitted CHR and HC. CHR converters had lower fronto-central P300 novel amplitude as well as marginally lower P300 oddball amplitude relative to HC. When CHR non-converters were stratified into remitted and non-remitted subgroups, P300 novel amplitude in remitted CHR subjects was comparable to HC, and it was higher than that in CHR subjects who converted to psychosis or who did not remit. Thus, reduced P300 novel amplitude indexing impaired salience processing marked both conversion to psychosis and remission from psychotic symptoms. (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

Free