Cortical gray matter reduction precedes transition to psychosis in individuals at clinical high-risk for psychosis: A voxel-based meta-analysis

SCHIZOPHRENIA RESEARCH

卷:232

Article

Fortea, Adriana^1,2,3  Batalla, Albert⁴  Radua, Joaquim^5,6,7,8  van Eijndhoven, Philip^9,10  Baeza, Inmaculada^1,3,5,6  Albajes-Eizagirre, Anton^5,6  Fusar-Poli, Paolo^7,11  Castro-Fornieles, Josefina^1,3,5,6  De la Serna, Elena⁶  Luna, Licia P.¹²  Carvalho, Andre F.^13,14  Vieta, Eduard^5,6,15  Sugranyes, Gisela^1,2,5,6 

[1] Hosp Clin Barcelona, Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, 2017SGR881,Villarroel 170, Barcelona 08036, Spain

[2] Esther Koplowitz Ctr, Fundacio Clin Recerca Biomed, Rossello 153, Barcelona 08036, Spain

[3] Univ Barcelona, Med & Recerca Traslac, Casanova 143, Barcelona 08036, Spain

[4] Univ Utrecht, UMC Utrecht Brain Ctr, Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands

[5] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Rossello 149, Barcelona 08036, Spain

[6] Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain

[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Early Psychosis Intervent & Clin Detect EPIC Lab, Dept Psychosis Stud, London, England

[8] Karolinska Inst, Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden

[9] Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands

[10] Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, Nijmegen, Netherlands

[11] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[12] Johns Hopkins Univ Hosp, Div Neuroradiol, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St Phipps B100F, Baltimore, MD 21287 USA

[13] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[14] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[15] Univ Barcelona, Hosp Clin, Inst Neurosci, Barcelona Bipolar Disorders & Depress Unit, Villarroel 170, Barcelona 08036, Spain

关键词: Clinical high-risk for psychosis;    Early psychosis;    Meta-analysis;    Neuroimaging;    VBM;    Cortical thickness;   

DOI  :  10.1016/j.schres.2021.05.008

来源: Elsevier

【 摘 要 】

Gray matter and cortical thickness reductions have been documented in individuals at clinical high-risk for psy-chosis and may be more pronounced in those who transition to psychosis. However, these findings rely on small samples and are inconsistent across studies. In this review and meta-analysis we aimed to investigate neuroan-atomical correlates of clinical high-risk for psychosis and potential predictors of transition, using a novel meta-analytic method (Seed-based d Mapping with Permutation of Subject Images) and cortical mask, combining data from surface-based and voxel-based morphometry studies. Individuals at clinical high-risk for psychosis who later transitioned to psychosis were compared to those who did not and to controls, and included three sta-tistical maps. Overall, individuals at clinical high-risk for psychosis did not differ from controls, however, within the clinical high-risk for psychosis group, transition to psychosis was associated with less cortical gray matter in the right temporal lobe (Hedges'g =-0.377), anterior cingulate and paracingulate (Hedges'g =-0.391). These findings have the potential to help refine prognostic and etiopathological research in early psychosis. (c) 2021 Elsevier B.V. All rights reserved.

【 授权许可】

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