Reproducibility of brain activation during auditory verbal hallucinations

SCHIZOPHRENIA RESEARCH

卷:146

Article

Diederen, K. M. J.^1,2  Charbonnier, L.³  Neggers, S. F. W.^1,2  van Lutterveld, R.^1,2  Daalman, K.^1,2  Slotema, C. W.⁴  Kahn, R. S.^1,2  Sommer, I. E. C.^1,2 

[1] Univ Med Ctr Utrecht, Div Neurosci, NL-3584 CX Utrecht, Netherlands

[2] Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Image Sci Inst, NL-3584 CX Utrecht, Netherlands

[4] Parnassia Bavo Grp, The Hague, Netherlands

关键词: Auditory verbal hallucinations;    fMRI;    Reproducibility;    rTMS;    Neurostimulation;   

DOI  :  10.1016/j.schres.2013.01.025

来源: Elsevier

【 摘 要 】

Previous studies investigated fMRI-guided repetitive Transcranial Magnetic Stimulation (rTMS) as an alternative treatment for auditory verbal hallucinations (AVH). This tailor-made treatment focuses at directing the rTMS coil to the location where hallucinatory activation is maximal, as identified with fMRI scans of individual patients. For the effective use of such treatment it is important to determine whether brain activation during AVH can be reliably detected using fMRI. Thirty-three psychotic patients indicated the presence of AVH during two subsequent scans. Reproducibility was measured by calculating 1) the distance between local maxima of significantly activated clusters and 2) percentage overlap of activation patterns over the two scans. These measurements were obtained both in single subjects and on group-level in five regions of interest (ROIs). ROIs consisted of the areas that were most frequently activated during AVH. Scans were considered reproducible if the distance between local maxima was smaller than 2 cm, as rTMS-treatment may target an area of approximately 2-4 cm. The median distance between local maxima was smaller than 2 cm for all ROIs on single-subject level, as well as on group-level. In addition, on single-subject level median percentage overlap varied between 14 and 38% for the different ROIs. On group-level, this was substantially higher with percentages overlap varying between 34 and 98%. Based on these results, AVH-scans may be considered sufficiently reproducible to be suitable for fMRI-guided rTMS treatment. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

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