N-acetylaspartate concentration in psychotic disorders: T2-relaxation effects

SCHIZOPHRENIA RESEARCH

卷:232

Article

Kuan, Elliot^1,2  Chen, Xi^1,2  Du, Fei^1,2  Ongur, Dost^1,2 

[1] McLean Hosp, Belmont, MA USA

[2] Harvard Med Sch, Boston, MA USA

关键词: T2 relaxation time;    N-acetylaspartate;    Psychotic disorder;    Schizophrenia;    Bipolar disorder;    Magnetic resonance spectroscopy (MRS);   

DOI  :  10.1016/j.schres.2021.04.012

来源: Elsevier

【 摘 要 】

We used proton magnetic resonance spectroscopy (H-1 MRS) to quantify N-acetylaspartate (NAA) concentrations and apparent spin-spin (T2) relaxation times, which also include diffusion attenuations, in first episode and chronic psychosis patients compared to matched healthy controls. 104 patients diagnosed with psychotic disorders and 50 matched controls were scanned at 4 Tesla. H-1 MRS data were collected at four echo times (TE = 30, 90, 150 and 200 ms) using PRESS. NM concentrations referenced to water and apparent T2 relaxation times of NM and water were calculated. At TE = 30 ms, NM concentration without T2 correction was significantly lower in chronic psychosis patients compared to age-matched healthy controls (p = 0.013, N = 61 and 26, respectively) but normal in first episode patients compared to matched controls (N = 43 and 24, respectively). After T2 correction, no significant differences remained between the groups. While diffusion attenuation was not independently accounted for, these findings indicate that T2 relaxation makes a major impact on NM concentration measures in psychotic disorders. Thus, it may be neuronal microenvironment indexed by NAA and water T2 relaxation times and not neuronal integrity indexed by NAA concentration that underlies the widely reported NM concentration reductions in psychotic disorders. (C) 2021 Elsevier B.V. All rights reserved.

【 授权许可】

Free