North American Prodrome Longitudinal Study (NAPLS 3): Methods and baseline description

SCHIZOPHRENIA RESEARCH

卷:243

Article

Addington, Jean^1,13  Liu, Lu¹  Brummitt, Kali¹  Bearden, Carrie E.²  Cadenhead, Kristin S.³  Cornblatt, Barbara A.⁴  Keshavan, Matcheri^5,6  Mathalon, Daniel H.^7,8  McGlashan, Thomas H.⁹  Perkins, Diana O.¹⁰  Seidman, Larry J.^5,6  Stone, William^5,6  Tsuang, Ming T.^3,11  Woods, Scott W.⁹  Cannon, Tyrone D.¹² 

[1] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada

[2] UCLA, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

[3] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA

[4] Zucker Hillside Hosp, Dept Psychiat, Long Isl City, NY USA

[5] Beth Israel Deaconess Med Ctr, Harvard Med Sch, Dept Psychiat, Boston, MA USA

[6] Massachusetts Gen Hosp, Boston, MA USA

[7] UCSF, Dept Psychiat, San Francisco, CA USA

[8] SFVA Med Ctr, San Francisco, CA USA

[9] Yale Univ, Dept Psychiat, New Haven, CT USA

[10] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[11] Univ Calif, Inst Genom Med, La Jolla, CA USA

[12] Yale Univ, Dept Psychol, New Haven, CT USA

[13] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada

关键词: Psychosis;    Schizophrenia;    Clinical high risk;    Methodology;   

DOI  :  10.1016/j.schres.2020.04.010

来源: Elsevier

【 摘 要 】

The North American Prodrome Longitudinal Study (NAPLS) is a consortium of nine programs focusing on youth at clinical high risk (CHR) for psychosis. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University, Harvard University, University of Calgary, University of California at Los Angeles, at San Diego, and at San Francisco, University of North Carolina Chapel Hill, Yale University, and Zucker Hillside Hospital. There have been two previous endeavors completed by this consortium, known as NAPLS-1 and NAPLS-2. This paper first offers an overview of the methodology of the third phase of the NAPLS consortium, the second five-year prospective study NAPLS-3, which aims to determine mechanisms of the development of psychosis. In addition, we report on the ascertainment and demographics of the 710 CHR participants in NAPLS-3. (c) 2020 Elsevier B.V. All rights reserved.

【 授权许可】

Free