Next-generation negative symptom assessment for clinical trials: Validation of the Brief Negative Symptom Scale

SCHIZOPHRENIA RESEARCH

卷:142

Article

Strauss, Gregory P.¹  Keller, William R.¹  Buchanan, Robert W.^1,2  Gold, James M.¹  Fischer, Bernard A.^1,2  McMahon, Robert P.¹  Catalano, Lauren T.¹  Culbreth, Adam J.¹  Carpenter, William T.^1,2  Kirkpatrick, Brian³ 

[1] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21228 USA

[2] VA Maryland Hlth Care Syst, Baltimore, MD USA

[3] Texas A&M Coll Med, Scott & White Healthcare, Temple, TX USA

关键词: Anhedonia;    Avolition;    Asociality;    Blunted Affect;    Alogia;   

DOI  :  10.1016/j.schres.2012.10.012

来源: Elsevier

【 摘 要 】

The current study examined the psychometric properties of the Brief Negative Symptom Scale (BNSS), a next-generation rating instrument developed in response to the NIMH sponsored consensus development conference on negative symptoms. Participants included 100 individuals with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder who completed a clinical interview designed to assess negative, positive, disorganized, and general psychiatric symptoms, as well as functional outcome. A battery of anhedonia questionnaires and neuropsychological tests were also administered. Results indicated that the BNSS has excellent internal consistency and temporal stability, as well as good convergent and discriminant validity in its relationships with other symptom rating scales, functional outcome, self-reported anhedonia, and neuropsychological test scores. Given its brevity (13-items, 15-minute interview) and good psychometric characteristics, the BNSS can be considered a promising new instrument for use in clinical trials. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free