Thalamo-cortical communication, glutamatergic neurotransmission and neural oscillations: A unique window into the origins of ScZ?

SCHIZOPHRENIA RESEARCH

卷:180

Article

Pratt, Judith¹  Dawson, Neil²  Morris, Brain J.³  Grent-'t-Jong, Tineke³  Roux, Frederic⁴  Uhlhaas, Peter J.³ 

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland

[2] Univ Lancaster, Div Biomed & Life Sci, Lancaster, England

[3] Univ Glasgow, Inst Neurosci & Psychol, Hillhead Str 58, Glasgow G12 8QB, Lanark, Scotland

[4] Univ Birmingham, Sch Psychol, Birmingham, W Midlands, England

关键词: Thalamus;    Schizophrenia;    Neural oscillations;    NMDA-receptors;    Glutamate;   

DOI  :  10.1016/j.schres.2016.05.013

来源: Elsevier

【 摘 要 】

The thalamus has recently received renewed interest in systems-neuroscience and schizophrenia (ScZ) research because of emerging evidence highlighting its important role in coordinating functional interactions in cortical-subcortical circuits. Moreover, higher cognitive functions, such as workingmemory and attention, have been related to thalamo-cortical interactions, providing a novel perspective for the understanding of the neural substrate of cognition. The current reviewwill support this perspective by summarizing evidence on the crucial role of neural oscillations in facilitating thalamo-cortical (TC) interactions during normal brain functioning and their potential impairment in ScZ. Specifically, wewill focus on the relationship betweenNMDA-Rmediated (glutamatergic) neurotransmission in TC-interactions. To this end, we will first review the functional anatomy and neurotransmitters in thalamic circuits, followed by a review of the oscillatory signatures and cognitive processes supported by TC-circuits. In the second part of the paper, data from preclinical research as well as human studies will be summarized that have implicated TC-interactions as a crucial target for NMDA-receptor hypofunctioning. Finally, wewill compare these neural signatureswith current evidence fromScZ-research, suggesting a potential overlap between alterations in TC-circuits as the result of NMDA-R deficits and stage-specific alterations in large-scale networks in ScZ. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free